Mast cells, extracellular matrix components, TGFbeta isoforms and TGFbeta receptor expression in labial salivary glands in systemic sclerosis
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چکیده
منابع مشابه
Immunoglobulin-containing cells in normal human labial salivary glands.
The distribution of immunoglobulin-containing cells within 8 normal human labial salivary glands was studied using an immunoperoxidase technique. Cell counts revealed that IgA-containing cells pre-dominated in all specimens and that the mean percentage class ratios for IgG:IgA:IgM:IgD cells were 4:92:3:1. IgE cells were rare and only detected in one gland. The density of IgA cells (191 cells/mm...
متن کاملRole of TGFbeta/Smad signaling in gremlin induction of human trabecular meshwork extracellular matrix proteins.
PURPOSE The bone morphogenic protein (BMP) antagonist gremlin is elevated in glaucomatous trabecular meshwork (TM) cells and tissues and elevates intraocular pressure (IOP). Gremlin also blocks BMP4 inhibition of transforming growth factor (TGF)-β2 induction of TM extracellular matrix (ECM) proteins. The purpose of this study was to determine whether Gremlin regulates ECM proteins in cultured h...
متن کاملSolution structure and backbone dynamics of the TGFbeta type II receptor extracellular domain.
Isoforms of transforming growth factor beta (TGFbeta) are 25 kDa homodimeric polypeptides that signal by binding and bringing together two related, functionally distinct cell surface receptors designated as TbetaR1 and TbetaR2. Here, we report the solution structure of the 13.8 kDa extracellular domain of human TbetaR2 (ecTbetaR2) as calculated from N(N)-H(N), C(alpha)-H(alpha), and C(alpha)-C(...
متن کاملTGFbeta-Smad signalling in postoperative human lens epithelial cells.
AIMS To localise Smads3/4 proteins in lens epithelial cells (LECs) of fresh and postoperative human specimens. Smads3/4 are involved in signal transduction between transforming growth factor beta (TGFbeta) cell surface receptors and gene promoters. Nuclear localisation of Smads indicates achievement of endogenous TGFbeta signalling in cells. METHODS Three circular sections of the anterior cap...
متن کاملObservations of Nerve Terminals in Human Labial Salivary Glands
The existence of a motor innervation to the secretory and myoepithelial elements of salivary glands has been supported amply by physiological and pharmacological studies extending over a century (reviewed in Babkin, 1950 ; Emmelin, 1967) . However, the exact morphological nature of this innervation at the acinar level is less well established, and has been the subject of several conflicting rep...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2000
ISSN: 0003-4967
DOI: 10.1136/ard.59.3.183